history of science

With reference to the scientific progress of ancient India, which of the statements given below are correct?

1. Different kinds of specialized surgical instruments were in common use by 1st century AD. 3rd
2. Transplant of internal organs in the human body had begun by the beginning of century AD
3. The concept of sine of an angle was known in 5th century AD
4. The concept of cyclic quadrilaterals was known in 7th century AD

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